Longitudinal ‘Half-and-Half Nails' or True Leukonychia

Half and half nails

This 68-year-old patient with Stage 4 chronic kidney disease was reviewed in our low clearance clinic 2 months after formation of a left arteriovenous fistula. The prominent ‘half-and-half’ appearance of his nails was noted. Nail disorders are common in chronic renal failure, affecting up to 70% of haemodialysis patients [1]. Half-and-half or Lindsay nails [2], where the proximal half of the na...

Half and half nails (Lindsay's nails) in chronic renal disease.

A 19 year old male, student, presented with a history of progressive loss of vision from right eye since one and half year and from the left eye since one year. The patient also complained of multiple episodes of generalized seizures three months back. Patient was diagnosed with tubercular choroiditis with chronic kidney disease with seizure disorder. The patient was evaluated but no intracrani...

Half-and-half nails in a patient on antituberculosis treatment.

To cite: Chadwick A, Thwaites V, Holland M, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2017219841 DESCRIPTION A Nigerian-born British national aged 24 years presented to our tuberculosis (TB) clinic after a positive, screening, quantiFERON blood test. She had been in the country for 12 years, had no known exposure to TB and no previous medical history....

Half empty or half full?

Synaptic Vesicles: Half Full or Half Empty?

The regulation of quantal size through pre- rather than postsynaptic mechanisms has recently received considerable attention as a potential mechanism for plasticity. Vesicular transporters catalyze the filling of synaptic vesicles with transmitter and are thus potential substrates for such presynaptic regulation. In this issue of Neuron, Prado et al. pursue this line of investigation and show t...